1/1/2024 0 Comments Integrity plus fort collins![]() 2002) and exhibits H3- and H4-specific inhibitor of acetyltranferase activity (INHAT) ( Ko et al. As DEK has been implicated in HDACII recruitment activities ( Hollenbach et al. 1A), and accumulation of cells in the G 2/M phase of the cell cycle ( Fig. Strikingly, the polyclonal DEK knockdown (DEKkd) cell lines showed a reduced growth rate ( Fig. In order to address this question, we knocked down DEK expression in human cells using several nonredundant shRNAs targeting DEK mRNA that were delivered by two independent lentiviral systems (shDEK) ( Fig. Our goal in this study was to gain a broader insight into DEK's in vivo functions. However, the biological functions of DEK have remained only incompletely understood. 2009 Riveiro-Falkenbach and Soengas 2010). 2009a, b) and a potential target for chemotherapy in malignant melanoma ( Khodadoust et al. DEK is significantly overexpressed in difficult-to-treat cancers, and was identified recently as a bona fide oncoprotein ( Wise-Draper et al. 2006 Gamble and Fisher 2007 Sawatsubashi et al. 1992), multiple studies identified pleiotrophic intranuclear functions of DEK, which may be regulated by distinct post-translational modifications (see also Supplemental Fig. Subsequent to its initial discovery as part of a fusion protein in a form of acute myeloid leukemia (AML) ( von Lindern et al. ![]() 2004 Riveiro-Falkenbach and Soengas 2010). ![]() 2001) that is conserved across species, and is the only member of its protein class (for review, see Sitwala et al. DEK is an abundant and structurally unique constituent of metazoan chromatin ( Kappes et al.
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